Systems: Overview

Illumina offers three distinct platforms for analyzing genetic variation and function— BeadArray technology on the iScan System, VeraCode technology on the BeadXpress Reader, and Illumina sequencing-by-synthesis technology on the Genome Analyzer. Each uses a unique chemistry that enables you to perform your experiment in less time, using fewer resources, and at a lower cost— without sacrificing data quality or amount.

Genome Analyzer	iScan System	BeadXpress Reader
Technology
Illumina Sequencing	BeadArray	VeraCode
Applications
DNA sequencing	SNP analysis	SNP analysis
transcriptome analysis	CNV discovery and analysis	methylation analysis
gene regulation and control	methylation analysis
protein-nucleic acid interactions (ChIP-Seq)	whole-genome expression profiling	expression profiling on FFPE or partially degraded samples
	expression profiling of FFPE or partially degraded samples	protein analysis
	microRNA profiling
Product Videos
Genome Analyzer sequencing video	iScan integrated array and sequencing video	VeraCode demo video

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1. DNA Analysis Solution

DNA Analysis Solutions: Overview

The Illumina story began with genotyping. As a major contributor and technology provider for the first phase of the International HapMap Project, GoldenGate Genotyping technology became the industry standard. Today, Illumina’s offers a powerful and comprehensive suite of tools for DNA analysis including high-throughput sequencing, whole-genome genotyping, analysis of structural variation, custom genotyping, methylation profiling, and low-to mid-plex DNA analysis.

Discovery applications
The Genome Analyzer, powered by Illumina Sequencing technology, is a high-throughput sequencing system that generates >25 Gb of data per run at 1/100th the cost of conventional sequencing. The system’s ease of use enables you to go from DNA to data in less than a week. The Genome Analyzer supports a broad range applications including genome sequencing, SNP and CNV discovery, targeted resequencing, and the study of structural genomic variation.

High-throughput whole-genome analysis
Illumina remains at the forefront of genotyping technologies with a new generation of high-density, multi-sample Infinium HD products that support integrated SNP and copy number variation (CNV) analysis. Infinium HD BeadChips deliver the industry's highest call rates and reproducibility for genome-wide association studies plus low noise for precise copy number measurements. Take the fastest path to discovery and publication by reading multi-sample InfiAnium HD BeadChips with the iScan System.

Validation, screening, and standard testing procedures
The BeadXpress Reader using VeraCode technology is the industry’s optimal solution for high-throughput analysis in the low to mid-plex screening. It offers the broadest multiplexing range, 1-384 assays per sample and the ability to process up to 96 samples in parallel for flexible, customizable, and cost-effective analysis.

• Sequencing
• Whole-genome SNP genotyping and CNV analysis
• Focused and custom SNP genotypingv
• Linkage analysis
• Validation, screening, and molecular testing
• Mmethylation profiling

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2. RNA Analysis Solution

RNA Analysis Solutions: Overview

Whether you want to look at entire genomes or focused gene sets, intact RNA samples or partially-degraded RNA, standard or custom panel content, Illumina gene expression solutions can help you. With our high feature redundancy, low sample input requirements, and industry-leading prices, you can get more of what you want within the same budget.

• Genome-wide expression
• DASL gene expression
• Digital gene expression
• MicroRNA Expression Profilingv

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3. Sequencing Applications

Genome Analyzer Applications: Overview

Now even the smallest lab can run the same powerful experiments as the largest genome centers with the Genome Analyzer. This ultra high-throughput sequencing system enables a wide range of genetic analysis applications from resequencing to de novo sequencing, transcriptome profiling to the study of regulatory mechanisms. The unparalleled combination of flexible read lengths and unique paired-end insert size range supports the highest coverage across complex genomes and enables you to go where the biology takes you.

Powered by Illumina Sequencing technology, the Genome Analyzer is capable of generating tens of billions of bases of data per week with the highest percentage of perfect reads. Offering the fastest and least labor-intensive workflow of any sequencing technology, the Genome Analyzer increases the pace of your discoveries.

Highlights

• Superior Accuracy: Produce the greatest percentage of perfect reads; generate quality results with fewer runs
• Simplest Workflow: Go from sample to data in less than a week with just one user and minimal hands-on time
• Highest Rate of Daily Output: Complete large studies in weeks instead of years
• Unprecedented Rate of Publication: Leverage robust performance and an easy workflow for faster publication of groundbreaking studies, as demonstrated by researchers around the world

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4. Veracode Applications

Veracode Applications: Overview

Whether beginning your study, validating your discoveries, or customizing assays for focused analysis, VeraCode technology offers you a comprehensive solution for your evolving laboratory objectives. This versatile platform supports DNA-, RNA-, and protein-based assays and delivers industry-leading data quality across a wide spectrum of customizable molecular testing applications. With the broadest multiplexing range in the industry, VeraCode technology allows you to assay 1 to 384 analytes in a single reaction in a standard 96-well microplate.

At the heart of VeraCode technology are two breakthrough innovations: the VeraCode digital microbead, and the BeadXpress Reader System. Together they deliver unprecedented data precision and verifiability, and enable customizable tracking of your samples and other critical identifiers. Downstream data analysis is made simple with the user-friendly VeraScan software that comes with the BeadXpress Reader. Advanced data analysis tools are available with Illumina's BeadStudio software, or third-party data analysis tools.

The streamlined workflow and low cost per assay make VeraCode technology an optimal solution for small and high-throughput laboratories conducting molecular testing applications such as biomarker validation, screening, pharmaceutical development, agriculture, and clinical research.

Learn more about what you can do with VeraCode technology.

• Genotyping
• Protein Analysis
• Methylation
• Gene Expression

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