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Case Studies
At Premas Biotech, we have completed a large number of deliveries, which have included purified proteins and lab reagents, purified native toxins of very high molecular weight, cell based assays, potency assays, proprietary mammalian expression vectors, etc.
Our clients include several large global pharma companies located over USA, Europe and the UK as well as some of biggest names of Indian Pharma. We have been working with UCB Celltech, UK on a large multi-project delivery. Furthermore, we have tied up with Sigma-Aldrich, USA in their newly launched Service Provider Network, after a 3 month long due diligence.
In view of confidentiality non-disclosure, we have listed some of our projects, with the highest possible degree of restraint.
Selected brief of the some of the Contract Research, Contract Manufacturing and Self sponsored Projects completed at PREMAS Biotech
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Sr. No.
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Sponsor
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Brief Description
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CS 1
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Global Pharma Co, UK
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Expression & purification of more than 20 proteins, with 3 media variations, inducer variation, etc. Deliverable - Milligrams of Proteins
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CS 2
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Global Pharma Co, UK
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Expression of five membrane associated proteins with high purity. Deliverable – Milligrams of Proteins
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CS 3
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Global Pharma Co, UK
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Technology transfer and manufacturing of fragment antibodies, Deliverable - Multi = gram levels of Proteins
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CS 4
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Global Pharma Co, France
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Expression & purification of membrane associated proteins, with 3 structural variants, inducer variation, expression vector selection, etc. Deliverable - Milligrams of Proteins
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CS 5
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Global Pharma Co, France
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Expression & purification of membrane associated protein, with inducer variation, expression vector selection, etc. Deliverable - Milligrams of Proteins
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CS 6
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Life Sciences Co, USA
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To compare the two different cell culture media for the CHO- suspension cell line producing a biotherapeutic under specified parameters (viability, MCB creation, specific productivity, etc), as well timeline delivery along with appropriate communication methods.
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CS 7
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Global Pharma Co, UK
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Delivery of more than 10 highly purified proteins, from native strains, of greater than 450 - 550 KDa, in extremely pure form (>99% purity) whereby monoclonal antibody probing with cross functional antibodies using ELISA did not pick up any residual contaminating proteins.
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CS 8
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Global Pharma Co, India
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Immuno-potentiation assay development for potency assay, for 'lot release" assay development for biogeneric release in regulated markets.
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CS 9
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Global Pharma Co, India
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Customized “focus” ELISA kit for "lot release" assay development for biogeneric release in regulated markets. This is to eliminate the lot to lot variability with generic ELISA test kits.
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CS 10
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Global Pharma Co, India
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Development of a customized reporter gene assay for determining the potency of a bio-therapeutic and subsequent development of a stable cell line for a customized reporter gene assay.
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CS 11
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Global Pharma Co, India
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Development of a mammalian vector for the expression of biotherapeutics.
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CS 12
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Internal Project
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Development of the CYP P450 suite of enzymes (8 enzymes) and the total production & process development.
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CS 13
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Internal Project
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Development of Angiogenic Potential Reporter Gene Assay. This assay measures the potential of a NCE (new chemical entity) or biotherapeutic to cause angiogenesis.
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CS 14
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Internal Project
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Development of Heavy Metal Reporter Gene Assay. This assay measures the presence and toxicity potential of heavy metals in a mixture.
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CS 15
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Internal Project
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Development of a proprietary Molecular Diagnostic Platform, which has been successfully been demonstrated for MTB, M. Bovis (pathogenic forms of TB), viral diseases, etc. Premas Biotech is actively soliciting out-licensing opportunities in this area.
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Potency Assay
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Purified Proteins
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P450 CO reduced differential spectra
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Purified protein
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